Table 2.

Organ-specific perfusion pressures and predominant vasoconstrictor receptors

Organ	Perfusion pressure	Predominant vasoconstrictor receptors
Brain	MAP–(CVP or ICP)*	α1, α2, angiotensin, vasopressin, endothelin, dopamine, neuropeptide Y, endothelial purinergic, 5-HT1B, endothelial purinergic
Heart	DAP–(CVP or ITP)*	α1, α2, angiotensin, vasopressin, endothelin, thromboxane, dopamine
Kidney	MAP–(CVP or IAP or IRP)*	α1, α2, angiotensin, vasopressin, endothelin, sphingosine-specific G protein-coupled
Gut	MAP–(CVP or IAP)*	α1, α2, angiotensin, vasopressin, endothelin, neuropeptide Y, constrictor prostaglandins
Liver	Hepatic artery: MAP–(CVP or IAP)* Portal vein: portal vein pressure—(CVP or IAP)*	α1, α2, angiotensin, vasopressin, endothelin, COX1-derived prostanoids, thromboxane

DAP = diastolic arterial pressure; CVP = central venous pressure; HT1B = hydroxytryptamine receptor 1B;

IAP = intra-abdominal pressure; ITP = intrathoracic pressure, IRP = intrarenal pressure (the kidney is surrounded by a non-distensible membrane and sensitive to interstitial edema)

*Whatever pressure is higher