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. 2022 Dec 1;22:376. doi: 10.1186/s12935-022-02799-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Sequence coverage and interaction heat map for Wnt pathway interactome. A amino acid coverage of protein pairs. The 60 clones interrogated in this study are listed alphabetically. A value of 1 indicates 100% sequence coverage (red) for the protein pair, while a value of 0 indicates zero coverage for a given protein pair (light red). B The protein pairs in panel A were tested for interactions by selection in the presence of 3-AT. Interactions were filtered based on Log₂FC > 1.5 and FDR < 0.05. A value of 4 indicates a strong interaction with high Log₂FC and minimum FDR, whereas a value of 1 indicates no interaction. Proteins paired with AD are represented on the x-axis, while proteins paired with DBD are represented on the y-axis