Table 3.
Association between predominant variant at time of COVID-19 infection and the composite severe disease.
| Effect | Model 1a |
Model 2b |
|---|---|---|
| ORa (95% CI) | aORb (95% CI) | |
| Predominant variant at time | ||
| T1 (Alpha) | Reference | Reference |
| T2 (Delta) | 0.66 (0.41–1.07) p = 0.092 | 0.68 (0.41–1.12) p = 0.129 |
| T3 (Omicron) | 0.41 (0.26–0.66) p < 0.001 | 0.35 (0.21–0.60) p < 0.001 |
Abbreviations: aOR = adjusted odds ratio; CI = confidence interval; OR = odds ratio; T1 = time period 1 (1/1/21–6/30/21); T2 = time period 2 (7/1/21–12/31/21); T3 = time period 3 (1/1/22–6/16/22).
a
Unadjusted multivariable logistic regression analysis in the hospitalized cohort.
b
Adjusted multivariable logistic regression analysis in the hospitalized cohort, adjusting for age group, gender, race, body mass index, and vaccination status.