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. 2022 Dec 1;12:20765. doi: 10.1038/s41598-022-24727-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrograph of heart tissue sections in different studied groups using Masson’s trichrome staining. (A) Control group exhibited a minimal amount of collagen fiber deposition around blood vessels (×200); (B) model group (dexamethasone-treated group) showed prominent and dense collagen fibrosis in the left ventricle (×400); fibrosis occurred in both interstitial and perivascular regions in an unorganized manner; (C) PRV 0.5 mg/kg; (D) PRV 1 mg/kg; (E) PRV 2 mg/kg with less fibrosis (×400). (F) Losartan treatment reduces cardiac fibrosis and collagen fibers are deposited around blood vessels (arrows) (×400).