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. 2022 Dec 1;12:20765. doi: 10.1038/s41598-022-24727-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrograph of aorta tissue sections in different studied groups. (H&E) (A) Control group: the tunica intima (arrowhead) faces the lumen. The tunica media is composed of elastic fibers and smooth muscle (thick arrow). The tunica adventitia is the outermost layer, which is composed of loose connective tissue (arrow) (A1,A2, respectively; ×100, ×200); (B1,B2) model group (dexamethasone- treated group) exhibited pathological changes, including lumen bulging and medial inflammatory cell infiltration (arrow), as well as an increase in the tunica media thickness overall (B1, ×200 and B2, ×400); (C) PRV 0.5 mg/kg there was a decrease in wall thickness associated with crystalloid material deposition (arrow); (D) PRV 1 mg/kg showed a decrease in wall thickness with organization of muscular fibers, with focal areas of disrupted endothelial cell lining fibrillation and focal subintimal hemorrhage (×200); (E) PRV 2 mg/kg with nearly normal endothelial lining and normal muscle structure (×200); (F) losartan-treated group with reduced intimal thickness.