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. 2022 Dec 1;12:20765. doi: 10.1038/s41598-022-24727-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrograph of kidney tissue sections in different studied groups. (H&E) (A) control group with normal histological structure of glomeruli and tubules (H&E ×200); (B1,B2) model group (dexamethasone-treated group) interstitial hemorrhage (arrow) ×100, hypercellular glomeruli (arrow) in (B3), ×400, obliterated tubules by swollen epithelial cells (zigzag arrow in B3); (C) PRV 0.5 mg/kg showing focally shrunken glomeruli and focally swollen hyalinized epithelial cells lining the tubules; (D) PRV1 mg/kg with well-formed glomeruli and tubules; (E) PRV 2 mg/kg exhibited a nearly normal histological renal pattern (E1, ×200) (arrows) with some inflammatory infiltrations (arrow E2); (F) losartan-treated group showing improved glomerular picture with interstitial vacuolation (F1, arrows), swollen hyalinized epithelial cells lining the tubules (arrows) were observed (F2, ×200).