TABLE 3.

Inducers and inhibitors of ferroptosis.

Classification	Reagents	Targets	References
Ferroptosis Inducers	Erastin	System Xc−, VDAC2/3, p53	(Dolma et al., 2003; Yang et al., 2020)
	Sulfasalazine	System Xc-	Gout et al. (2001)
	Sorafenib	Nrf2, Keap1, System Xc-	Louandre et al. (2015)
	ATF3	SLC7A11, GPX4	(Wang et al., 2020; Wang et al., 2021)
	Acetaminophen	GSH, GPX4	Mitchell et al. (1973)
	RSL3	NF-κB, GPX4	Yang et al. (2014)
	FINO2	GPX4, Fe2+	Gaschler et al. (2018)
	Lipopolysaccharide	SLC7A11, GPX4	Liu et al. (2020a)
	Legumain	GPX4	Chen et al. (2021)
	Dexamethasone	GSH	von Mässenhausen et al. (2022)
	DPI2	GSH	Yang et al. (2014)
	BSO	GSH	Yang et al. (2014)
	Cisplatin	GSH, GPX4	Yamaguchi et al. (2013)
	FIN56	GPX4, CoQ10	Shimada et al. (2016)
	Siramesine	FPN, Ferritin	Ma et al. (2016)
Ferroptosis inhibitors	Fer-1	Lipid peroxidation	Skouta et al. (2014)
	SRS 16–86	Lipid peroxidation	Skouta et al. (2014)
	SRS 11–92	Lipid peroxidation	Linkermann et al. (2014a)
	Liproxstatin-1	GPX4, Lipid peroxidation	Friedmann Angeli et al. (2014)
	Vitamin E	Lipid peroxidation	Hinman et al. (2018)
	Vitamin K	FSP1	Mishima et al. (2022)
	Quercetin (QCT)	MDA, ROS, GSH	Wang et al. (2021)
	Nuciferine	Lipid peroxidation	Li et al. (2021)
	Irisin	GPX4, Lipid peroxidation	Zhang et al. (2021b)
	VDR	GPX4, Lipid peroxidation	Hu et al. (2020)
	Ginsenoside Rg1	GPX4, GSH, FSP1	Guo et al. (2022)
	Entacapone	Nrf2	Yang et al. (2022b)
	MCTR1	Nrf2	Xiao et al. (2021)