Table 4.

Gene knockout studies in glaucoma or IR mouse models.

Mouse models	Knockout or mutated genes	Effects on RGCs	References
DBA/2J mice	Germline, C3	RGC loss↑	Harder et al. (2017)
DBA/2J mice	Germline, C3ar1	RGC loss↓	Harder et al. (2020)
DBA/2J mice	C1qa mutation	RGC loss↓	Howell et al. (2011)
OHT mice	Astrocytes specific, IκKβ or p65	RGC loss↓	Yang et al. (2020)
OHT mice	Germline, IL-1α, TNFα, and C1q	RGC loss↓	Guttenplan et al. (2020)
OHT mice	Astrocytes specific, Caspase 8	RGC loss↓	Yang et al. (2021)
OHT mice	Astrocytes specific, Stat 3	RGC loss↑	Sun et al. (2017)
OHT mice	Astrocytes specific, Cx43	RGC loss↑	Cooper et al. (2020)
IR mice	Astrocytes specific, Cx43	RGC loss↓	Toychiev et al. (2021)
OHT mice	Germline, C36	RGC loss↓	Akopian et al. (2017)
OHT mice	Astrocytes specific, Ucp2	RGC loss↓	Hass and Barnstable (2019)

IR, Ischemia-reperfusion retinal injury; OHT, Ocular hypertension. Up arrow indicates increased RGC loss, down arrow indicates decreased RGC loss.