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| alkaloid–acid system | absorption solubility (g L–1) |
|---|---|
| Theobromine Cocrystals | |
| TBR·TMSA | 0.35 (×1.06) |
| TBR·HMLA | 2.36 (×7.15) |
| Theophylline Cocrystals | |
| TPH·TMSA | 2.07 (×0.25) |
| TPH·TMSA·2H2O | 2.01 (×0.24) |
| TPH·HMLA | 9.6 (×1.16) |
| (TPH)+·(HMLA)−·2H2O | 147.9 (×17.82) |
| Caffeine Cocrystals | |
| CAF·TMSA | 1.37 (×0.09) |
| CAF·HMLA·H2O | 4.86 (×0.30) |
The increase relative to TBR, TPH, and CAF is shown in parentheses, respectively.
