| A |
Good evidence to support a recommendation for use |
| B |
Moderate evidence to support a recommendation for use |
| C |
Poor evidence to support a recommendation |
| D |
Moderate evidence to support a recommendation against use |
| E |
Good evidence to support recommendation against use |
| Quality of evidence |
|
| I |
Evidence from ≥1 properly randomized, controlled trial |
| II |
Evidence from ≥1 well-designed clinical trial, without randomization; from cohort or case-controlled analy- tic studies; from multiple time series; or from dramatic results from uncontrolled experiments |
| III |
Evidence from recommendations of respected authorities, based on clinical experience, descriptive studies, or reports of committees |
