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. 2022 Nov 17;13:1020670. doi: 10.3389/fphar.2022.1020670

FIGURE 5.

FIGURE 5

Low-dose GCV attenuated DSS-colitis in mice. (A) DSS-colitis induced body weight loss from different groups. (B) The quantification of AUC for (A). (C) DSS-colitis induced increase of DAI scores in different groups. (D) The quantification of AUC for (C). (E) DSS-colitis induced mechanical pain hypersensitivity in the abdomen in mice from different groups. (F) The quantification of AUC for (E). (n = 6-7 per group; * p < 0.05, ** p < 0.05, *** p < 0.001, DSS vs. vehicle group; # p < 0.05, ## p < 0.01, ### p < 0.001, GCV + DSS vs. DSS group; & p < 0.05, && p < 0.01, &&& p < 0.001, STINGgt/gt + DSS vs DSS group; two-way ANOVA with post-hoc Bonferroni test). (G) Representative pictures of colonic length from different groups. (H) Quantification of the colonic length for (G). (n = 5-7 each group; * p < 0.05, ## p < 0.01, & p < 0.05; one-way ANOVA with post-hoc Bonferroni test) (I) Representative photographies of H&E staining of colon sections from different groups. (J) Statistical analysis for (I) (n = 4 each group; *** p < 0.001, # p < 0.05, & p < 0.05; one-way ANOVA with post-hoc Bonferroni test). (K,L) The Q-PCR analysis of mRNA expression of colonic Cgas, Il10, Ifnb1, Cxcl10, Il1b, Il6, and Tnf in mice of different group (n = 6 per group, ** p < 0.01, *** p < 0.001, ## p < 0.01, ### p < 0.001; unpaired Student’s t-test). All data was expressed as Mean ± SEM. DSS, dextran sulfate sodium; VEH, vehicle.