Figure 6. Loss of Alk5 signaling in Macs but not in MPCs has a greater impact on trauma-induced HO.

(A) Graphic depicting experimental timeline for Hoxa11CreER^T2 mice. (B) MicroCT analysis of left injured hind limb 9 weeks postinjury for Hoxa11CreER^T2–/– Alk5^fl/fl compared with Hoxa11CreER^T2 Alk5^fl/fl (n = 11 and 7, respectively/group). Error bars represent mean ± SEM. (C) Graphic depicting experimental timeline for LysMCre mice. (D) MicroCT analysis of left injured hind limb 9 weeks postinjury for LysMCre^–/– Alk5^fl/fl and LysMCre^+/– Alk5^fl/fl (n = 12, 7, respectively/group). Error bars represent mean ± SEM or median ± interquartile range (tendinous and proximal HO only). *P < 0.05 (the data were parametric, as explained in the Methods section).