Table 5. Lung tissue microRNA expression.

Lung tissue microRNA expression/U6	miR-let-7d	miR-29	miR-181b	miR-199fibrotic	miR-34a fibrotic	miR-142 antifibrotic
PBS	0.18±0.03	2.1±0.4	0.26±0.06	0.03±0.001	0.07±0.02	0.23±0.016
Control U-exo	0.3±0.01 ##	2.8±0.7	0.3±0.07	0.06±0.003	0.09±0.01	0.19±0.03
U-IPFexo	0.14±0.02	0.48±0.1 *&	0.15±0.05	0.05±0.006 †	0.13±0.03 *	0.16±0.02 *
Bleomycin (Bleo)	0.057±0.009 ^^	0.17±0.02	0.009±0.001	0.19±0.02	0.18±0.05	0.23±0.04
Bleo +Control U- exo	0.24±0.05 †	0.17±0.02	0.008±0.001	0.35±0.11	0.18±0.02	0.29±0.05
Bleo +U-IPFexo	0.10±0.011 $$^^	0.20±0.17	0.004±.001 †	1.68±0.44 *$$^^	0.43±0.08 *$$^	0.16±0.01 &$^
Bleo +U-bronchiectasis exo	0.17±.03	0.14±0.03	ND	0.13±0.35	0.06±0.02	0.3±0.07
Bleo +U-asthma exo	0.39±0.1	0.11±0.01	ND	0.06±0.01	0.06±0.02	0.29±0.04

^* p<0.05 compared to control exosomes, &p<0.001 compared to control exosomes.

^† p<0.05 compared to Bleo, ##p<0.001 compared to Bleo, $p<0.05, $$ p<0.01 compared to bronchiectasis exosomes ^p<0.01 ^^ p<0.001compared to asthma exosomes. p values were calculated by Mann-Whitney U test. ND = not detected.