Figure 2.

TF regulation via motifs in the open chromatin peaks

(A) Heatmap showing the significantly enriched TF motifs in the open chromatin peaks of each cell type and condition. Colors represent −log₁₀ p value of enrichment. Rows are significantly enriched TF motifs.

(B) Track plots showing the peaks around the LUCAT1 gene. Blue lines indicate inferred linkages between peaks and LUCAT1 expression.

(C) Heatmap showing the expression correlation of LUCAT1, IFI27, and IFI30 and TF genes in classical monocytes of hospitalized patients with a dot plot showing the expression of these genes in different conditions.

(D) Boxplots showing the molecular responses after knockdown of SPI1 and LUCAT1 or inhibition of C/EBP proteins.

(E) Schematic plot summarizing the potential regulating program in LUCAT1, SPI1, and C/EBP, as well as ISG, and COVID-19 severity.

See also Figure S5 and Table S5.