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The mutagenic potency and toxicity evaluation result of the hits.
| Ligand | AMES toxicity | hMTD | hERG I inhibitor | hERG II inhibitor | ORAT (logLD50) | ORCT (log LOAEL) | Hepatotoxicity | Skin sensitisation | TP toxicity | Minnow toxicity |
|---|---|---|---|---|---|---|---|---|---|---|
| 4 | Yes | 0.468 | No | Yes | 2.659 | −1.768 | Yes | No | 0.285 | −9.215 |
| 5 | Yes | 0.307 | No | Yes | 2.531 | 2.583 | Yes | No | 0.285 | −0.499 |
The red colour indicates that the ligand does not meet the criteria of the corresponding parameter.
