Table 3.
Summary of the diagnostic performances of long non-coding RNAs in colorectal cancer.
| LncRNAs | Expression | CRC cases vs. controls | AUC | Sensitivity | Specificity | Sample | Reference |
|---|---|---|---|---|---|---|---|
| BLACAT1 | Up | 30 vs.30 | 0.858 | 83.3% | 76.7% | Serum | [162] |
| BCAR4 | Up | 76 vs.76 | 0.936 | NA | NA | Serum | [163] |
| KRTAP5-4, MAGEA3 and BCAR4 | - | 76 vs.76 | 0.857 | NA | NA | Serum | [163] |
| CRNDE-b | Up | 161 vs. 222 | 0.921 | 85% | 96% | Plasma | [164] |
| CRNDE-g | Up | 161 vs. 222 | 0.892 | 80% | 96% | Plasma | [164] |
| CRNDE-h | Up | 161 vs. 222 | 0.888 | 80% | 96% | Plasma | [164] |
| NEAT1 | Up | 100 vs. 100 | 0.787/0.871 | 69%/70%; | 79%/96% | Blood | [165] |
| 91H | Up | 76 vs.76 | 0.870 | 84.48% | 80.36% | Plasma | [166] |
| PVT-1 | Up | 76 vs.76 | 0.786 | 68.97% | 82.14% | Plasma | [166] |
| MEG3 | Down | 76 vs.76 | 0.819 | 75.86% | 82.14% | Plasma | [166] |
| GAS5 | Up | 76 vs.76 | 0.642 | 63.79% | 62.5% | Plasma | [166] |
| CCAT1-L | Up | 76 vs.76 | 0.748 | 75.86% | 73.21% | Plasma | [166] |
| 91H, PVT-1 and MEG3 | - | 76 vs.76 | 0.877 | 82.76% | 78.57% | Plasma | [166] |
| LINC00654 | Up | 114 vs.58 | 0.734 | NA | NA | Plasma | [167] |
| LINC00909 | Up | 114 vs.58 | 0.886 | NA | NA | Plasma | [167] |
| SNGH11 | Up | 114 vs.58 | 0.868 | NA | NA | Plasma | [167] |
| ZFAS1 | Up | 114 vs.58 | 0.850 | NA | NA | Plasma | [167] |
| ZFAS1, SNHG11, LINC00909 and | - | 0.937 | NA | NA | Plasma | [167] | |
| LINC00654 | |||||||
| LINC02418 | Up | 125 vs. 125 | 0.8978 | 95.2% | 66.4% | Serum | [169] |
| RP11-296E3.2 | Up | 60 CRC | 0.663 | 69.0% | 62.1% | Plasma | [171] |
| RP11-296E3.2 and CEA | - | 60 CRC | 0.722 | 72.4% | 71.4% | Plasma | [171] |
| BANCR, NR_026817, NR_029373, and NR_034119 | - | 120 vs. 120 | 0.881 | 89.17% | 75.83% | Serum and tissue | [168] |