Table 2.
Hematological parameter levels in normal mice treated with DI and PbANKA-infected mice treated with 60% DMSO, DFP-RVT (50 mg/kg), DFP (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, #p < 0.05 when compared with the normal group; and ∗p < 0.05 when compared with the PbANKA-infected group treated with DMSO. (b) WBC indices.
| Mice | Treatment | WBC number (×103/mL | Differential number (%) | ||||
|---|---|---|---|---|---|---|---|
| Neutrophil | Lymphocyte | Monocyte | Basophil | Eosinophil | |||
| Normal | DI | 3.10 ± 0.29 | 17.00 ± 5.00 | 80.00 ± 6.00 | 4.00 ± 0.01 | ND | ND |
| PbANKA-infected | DMSO | 16.22 ± 2.10# | 49.67 ± 3.33# | 46.33 ± 3.33# | 2.33 ± 0.33 | 1.00 ± 0.00 | 1.00 ± 0.58 |
| PbANKA-infected | PYR | 4.05 ± 0.14∗ | 35.00 ± 1.63 | 54.50 ± 3.67 | 7.67 ± 2.19 | 1.00 ± 0.00 | 0.50 ± 0.41 |
| PbANKA-infected | DFP | 11.99 ± 2.40 | 45.00 ± 3.51 | 51.33 ± 3.67 | 2.33 ± 0.33 | 1.00 ± 0.58 | 0.33 ± 0.33 |
| PbANKA-infected | DFP-RVT | 11.10 ± 1.73∗ | 46.50 ± 9.39 | 43.33 ± 9.61 | 3.00 ± 0.58 | 0.67 ± 0.33 | 0.67 ± 0.67 |
DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, ND = not detectable, PbANKA = Plasmodium berghei ANKA strain, and PYR = pyrimethamine.