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. 2022 Nov 24;2022:3869337. doi: 10.1155/2022/3869337

Table 3.

Levels of AST, ALT, and ALP activities in the plasma of normal mice and PbANKA-infected mice treated with 60% DMSO, DFP (50 mg/kg), DFP-RVT (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, #p  <  0.05 when compared with the normal group; and p  <  0.05 when compared with mice in the PbANKA-infected group that had been treated with DMSO.

Mice Treatment Liver enzyme activity
AST (U/L) ALT (U/L) ALP (U/L)
Normal DI 51.0 ± 1.4 25.6 ± 1.2 25.3 ± 0.4
PbANKA-infected DMSO 81.7 ± 0.7# 35.8 ± 2.2 45.8 ± 0.1#
PbANKA-infected PYR 68.5 ± 4.0 25.7 ± 3.7 30.0 ± 0.5
PbANKA-infected DFP 102.8 ± 3.7 36.2 ± 1.1 28.5 ± 0.3
PbANKA-infected DFP-RVT 80.8 ± 0.1 20.6 ± 0.6 30.5 ± 1.4

ALP = alkaline phosphatase, ALT = alanine aminotransferase, AST = aspartate aminotransferase, DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, PbANKA = Plasmodium berghei ANKA strain, and PYR = pyrimethamine.