Table 3.
Levels of AST, ALT, and ALP activities in the plasma of normal mice and PbANKA-infected mice treated with 60% DMSO, DFP (50 mg/kg), DFP-RVT (50 mg/kg), and PYR (2 mg/kg) (n = 3 each) for 8 consecutive days. Data are expressed as mean ± SEM values. Accordingly, #p < 0.05 when compared with the normal group; and ∗p < 0.05 when compared with mice in the PbANKA-infected group that had been treated with DMSO.
Mice | Treatment | Liver enzyme activity | ||
---|---|---|---|---|
AST (U/L) | ALT (U/L) | ALP (U/L) | ||
Normal | DI | 51.0 ± 1.4 | 25.6 ± 1.2 | 25.3 ± 0.4 |
PbANKA-infected | DMSO | 81.7 ± 0.7# | 35.8 ± 2.2 | 45.8 ± 0.1# |
PbANKA-infected | PYR | 68.5 ± 4.0 | 25.7 ± 3.7 | 30.0 ± 0.5∗ |
PbANKA-infected | DFP | 102.8 ± 3.7 | 36.2 ± 1.1 | 28.5 ± 0.3∗ |
PbANKA-infected | DFP-RVT | 80.8 ± 0.1 | 20.6 ± 0.6∗ | 30.5 ± 1.4∗ |
ALP = alkaline phosphatase, ALT = alanine aminotransferase, AST = aspartate aminotransferase, DFP = deferiprone, DFP-RVT = deferiproneresveratrol, DI = deionized water, DMSO = dimethylsulfoxide, PbANKA = Plasmodium berghei ANKA strain, and PYR = pyrimethamine.