Table 1. The distribution and the intensity of each marker at the different morphological structures.
Marker | TTF-1 | Napsin A | SP-A | CD44 | CD133 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Distribution of each marker | |||||||||||
Score | DS | IE | DS | IE | DS | IE | DS | IE | DS | IE | |
Primary | 2 | +++ | 2 | +++ | 1 | +++ | 3 | +++ | 2 | ++ | |
F1 | 1 | +++ | 1 | +++ | 1 | ++ | 2 | ++ | 1 | + | |
F2 | 0 | - | 0 | - | 1 | + | 1 | + | 1 | + | |
F2(C) | 0 | - | 0 | - | 1 | + | 2 | + | 1 | + | |
Intensity of each marker in the glandular and solid structure | |||||||||||
Structurea | G | S | G | S | G | S | G | S | G | S | |
Primary | +++ | - | +++ | - | - | +++ | +++ | +++ | +++ | ++ | |
F1 | +++ | - | +++ | - | - | +++ | +++ | ++ | ++ | + | |
F2 | - | - | - | - | - | + | + | + | + | + | |
F2(C) | - | - | - | - | - | + | ++ | ++ | + | + |
DS (distribution of staining) was scored according to the following criteria: 0 (tumor cells were negative), 1 (5%–25% positive tumor cells), 2 (25%–60% positive tumor cells) and 3 (more than 60% positive cells); IE (intensity expression score) was based on the followings: (−) negative; (+) weak; (++) moderate; (+++) strong.
aG, glandular structure; S, solid structure.