Table 5.
Health care resource utilisation post-commencement of first-line treatment of EGFRm+ mNSCLC
| Total (N = 162) | |
|---|---|
| Diagnostic and monitoring tests, annual rate (95% CI)a | |
| Chest X-ray | 12.9 (10.6–15.7) |
| Tumour markers | 1.8 (1.1–2.9) |
| CT | 5.1 (4.7–5.4) |
| MRI | 0.9 (0.6–1.2) |
| Bone scan | 1.2 (0.9–1.7) |
| PET | 0.5 (0.4–0.7) |
| Office visits, annual rate (95% CI)a | |
| Physician visits | 11.8 (9.3–15.0) |
| Oncologist | 6.5 (4.0–10.4) |
| Pulmonologist | 5.5 (3.7–8.1) |
| Outpatient hospital admission (no overnight stay) | 3.2 (1.4–7.3) |
| Emergency room visitsb | |
| Mean (SD) | 0.2 (0.65) |
| Annual per person-year rate of emergency room visits (95% CI)a | 0.2 (0.1–0.3) |
| Inpatient hospital admissionsc | |
| Mean (SD) | 0.3 (0.77) |
| Annual per person-year rate of hospitalisation (95% CI)a | 0.2 (0.1–0.4) |
| Length-of-stay per hospitalisation (days)d,e | |
| Mean (SD) | 10.4 (7.51) |
| Median (range) | 9.0 (2–29) |
| Reason for hospitalizationd,e | N = 42 |
| NSCLC treatment | 11 (26.2) |
| Diarrhoea | 5 (11.9) |
| Neoplastic pleural effusion; Pleural effusion due to malignancy; underlying neoplasm | 5 (11.9) |
| AE—decreased appetite | 4 (9.5) |
| Pneumonia | 3 (7.1) |
| Pain, neoplasm related pain | 2 (4.8) |
| Chronic lung disease | 1 (2.4) |
| Dermatitis acneiform | 1 (2.4) |
| Haemoptysis (coughing blood); blood-stained sputum; cough with haemorrhage | 1 (2.4) |
| Neutropenia | 1 (2.4) |
| Other | 8 (19.0) |
AE adverse event, CI confidence interval, CT computerised tomography, MRI magnetic resonance imaging, N total number of subjects, n number of subjects per category, NSCLC non-small-cell lung cancer, PET positron emission tomography, SD standard deviation
aRates per person-year with 95% CI are estimated from the negative binomial model
bNineteen (11.7%) patients had a total of 33 emergency room visits. Based on 160 patients with known emergency room visit records
cTwenty-six patients (16.0%) patients had a total of 42 hospital admissions
dInformation collected on most recent 5 hospitalisations per person only
eBased on the number of hospitalisations