TABLE 3.
List of the nineteen mol-miRs target genes in common between Homo sapiens and Mus musculus, with relative mol-miRs and binding energy shown as score.
| Genes | Description | Pathway | mol-miRs predicted for human genes | mol-miRs predicted for murine genes |
|---|---|---|---|---|
| AGT | Angiotensinogen | Hormones | miR160h (0.65), miR395d (0.96), miR482b (0.97) | miR160h (0.90), miR159c (0.90), miR167f-3p (0.96), miR397a (0.68) |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A | Tumorigenesis | miR395d (0.93), miR160h (0.96), miR166 (0.97) | miR160h (0.96) |
| CFD | Complement factor D | Adipokines | miR160h (0.95) | miR160h (0.97) |
| DIO2 | Deiodinase, iodothyronine, type II | Pro-Brown Adipose Tissue | miR166 (0.96), miR396a (0.99) | miR159c (0.94), miR156e (0.94), miR166 (0.87) |
| EGR2 | Early growth response 2 | Pro-White Adipose Tissue | miR166 (0.60), miR159c (0.82) | miR167f-3p (0.95), miR159c (0.94) |
| INSR | Insulin receptor | Pro-Brown Adipose Tissue | miR396a (0.85), miR482b (0.98) | miR395d (0.90) |
| KLF2 | Kruppel-like factor 2 | Anti-White Adipose Tissue | miR2118a (0.87), miR482b (0.96), miR166 (0.97) | miR166 (0.97), miR160h (0.88) |
| LEP | Leptin | Adipokines | miR159c (0.95), miR482b (0.96), miR160h (0.96), miR166 (0.98) | miR395d (0.95), miR159c (0.91), miR160h (0.92) |
| LPL | Lipoprotein lipase | Enzymes | miR160h (0.61) | miR167f-3p (0.65) |
| MAPK14 | Mitogen-activated protein kinase 14 | Pro-Brown Adipose Tissue | miR393a (0.92), miR396a (0.98) | miR159c (0.93) |
| NRF1 | Nuclear respiratory factor 1 | Pro-Brown Adipose Tissue | miR160h (0.94), miR396a (0.97), miR482b (0.98) | miR167f-3p (0.85) |
| PPARA | Peroxisome proliferator receptor alpha | Beta-Oxidation | miR393a (0.75), miR160h (0.96), miR166 (0.96) | miR397a (0.96), miR482b (0.94), miR160h (0.87) |
| RB1 | Retinoblastoma 1 | Anti-Brown Adipose Tissue | miR160h (0.86) | miR159c (0.61) |
| RXRA | Retinoid X receptor alpha | Cholesterol Metabolism & Transport | miR160h (0.97), miR166 (0.98) | miR160h (0.93), miR159c (0.93), miR398a-5p (061), miR166 (0.61) |
| SFRP1 | Secreted frizzled-related protein 1 | Pro-Adipogenesis | miR160h (0.84), miR166 (0.84), miR482b (0.97) | miR160h (0.92), miR166 (0.92) |
| SHH | Sonic hedgehog | Tumorigenesis | miR159c (0.95), miR482b (0.98) | miR858b (0.96), miR167f-3p (0.72) |
| VDR | Vitamin D receptor | Tumorigenesis | miR160h (0.71), miR166 (0.97) | miR160h (0.91), miR398a-5p (0.91), miR166 (0.63) |
| WNT3A | Wingless-related MMTV integration site 3A | Tumorigenesis | miR171b (0.87), miR166 (0.92), miR482b (0.94), miR2118a (0.96), miR160h (0.98) | miR159c (0.93), miR395d (0.85) |
| WNT10B | Wingless related MMTV integration site 10b | Tumorigenesis | miR166 (0.62), miR167f-3p (0.88), miR395d (0.96), miR482b (0.96), miR2118a (0.96), miR160h (0.98) | miR858b (0.96), miR167f-3p (0.94), miR160h (0.91) |