Duplicates removed	192
Excluded during initial screening (e.g. press releases; news reports; not relevant drug/indication; preclinical study; reviews; case reports; not randomized trial)	182
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	22
Cited efficacy/tolerability articles	10
Cited articles not efficacy/tolerability	16
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were sotorasib, LUMAKRAS, LUMYKRAS, AMG 510 and AMG510. Records were limited to those in English language. Searches last updated 5 Oct 22