Table 3.

The main toxicokinetic parameters of DQ, DQ-M and DQ-D in rats after intragastric administration of DQ at dose of 11 mg/kg (n = 6)

Toxicokinetic parameters	DQ	DQ-M	DQ-D
Cmax (ng/mL)	977 ± 301	47.1 ± 22.7	246 ± 81.8
Tmax (h)	0.6 ± 0.3	0.5 ± 0.2	1.6 ± 0.2
t1/2 (h)	13.1 ± 5.3	25.1 ± 20.2	8.2 ± 1.5
MRT0–t (h)	7.7 ± 2.4	10.9 ± 2.4	9.4 ± 1.2
MRT0–∞ (h)	12.3 ± 6.6	32.6 ± 27.2	11.9 ± 2.1
AUC0–t (h·ng/mL)	2770 ± 972	180 ± 50.6	2430 ± 1040
AUC0–∞ (h·ng/mL)	3050 ± 1180	257 ± 119	2560 ± 1090