Table 4.

Quantitative evidence synthesis for fatigue included in the 29 SRs/meta-analyses

Subgroup category	Number of reviews included	Number of original studies included	Number of participants included	Standardized mean difference (95% CI)	I-square (%)	Test for overall effect
						Z	P
Exercise type
Aerobic exercise	13	119	12,218	− 0.29 [− 0.56, − 0.02]	16.0	1.98	0.048
Resistance exercise	5	12	1,234	− 0.01 [− 0.31, 0.29]	48.0	0.05	0.958
Yoga	10	92	7,158	− 0.30 [− 0.56, − 0.05]	28.7	2.31	0.021
Tai chi	4	12	904	− 0.19 [− 1.13, 0.76]	75.2	0.38	0.702
Combination exercise	8	67	6,884	− 0.35 [− 0.76, 0.05]	38.8	1.72	0.086
Mind–body exercise	3	11	903	− 0.21 [− 0.63, 0.22]	45.1	0.96	0.336
Other exercise	4	23	2,209	− 0.09 [− 0.45, 0.26]	93.2	0.53	0.599
Overall	47	336	31,510	− 0.23[− 0.35, − 0.11]	95.0	3.84	0.000
Duration of intervention
Up to two months	4	20	2,067	− 0.55 [− 1.15, 0.06]	34.2	1.76	0.078
Two to six months	5	42	6,877	− 0.23 [− 0.65, 0.19]	59.1	1.06	0.288
More than six months	7	76	3,039	− 0.88 [− 1.59, − 0.17]	42.7	5.57	0.000
Overall	16	128	13,983	− 0.29[− 0.43, − 0.15]	94.8	4.04	0.000
Duration of exercise
30 to 60 min	5	54	5,028	− 0.81 [− 1.15, − 0.47]	42.3	5.56	0.000
More than 60 min	4	39	3,825	− 0.77 [− 1.04, − 0.50]	0.0	4.66	0.000
Overall	9	93	8,853	− 0.41 [− 0.56, − 0.26]	95.2	5.40	0.000
Frequency of exercise
Up to three times/week	5	68	4,045	− 0.75 [− 1.58, 0.08]	91.6	1.77	0.076
More than three times/week	4	81	2,672	− 0.65 [− 0.93, − 0.37]	33.0	4.63	0.000
Overall	9	149	6,717	− 0.37[− 0.50, − 0.23]	95.3	5.23	0.000
Supervised
Yes	7	63	6,511	− 0.48 [− 0.77, − 0.18]	87.0	1.02	0.001
No	6	56	5,376	− 0.21 [− 0.40, − 0.01]	92.2	0.98	0.023
Overall	13	119	11,887	− 0.29 [− 0.43, − 0.14]	95.9	3.90	0.000
Overall included	29	348	33,655	− 0.40 [− 0.58, − 0.22]	95.4	4.87	0.000