Table 2.

Concentrations and total amounts of BocMA and M1 (D1, 2) excreted in rat urine within the first 72 h

Rat no.	Time (h)	Urine volume (mL)	BocMAa (ng/mL)	BocMAb (ng)	Before hydrolysis	After hydrolysis		Before hydrolysis	After hydrolysis		Total percentage of the excreted BocMA (%)
					M1–D1a (ng/mL)	M1–D1a (ng/mL)	M1–D1b (ng)	M1–D2a (ng/mL)	M1–D2a (ng/mL)	M1–D2b (ng)
1	0–4	1.5	58	87	0.47	0.46	0.69	1.5	5.2	7.8	–
	4–8	1.0	8.9	8.9	0.51	54	54	0.67	35	35	–
	8–24	8.0	7.4	59	ND	ND	2.3	ND	ND	–	–
	24–48	7.0	12	84	ND	ND	–	ND	ND	–	–
	48–72	10	ND	–	ND	ND	–	ND	ND	–	–
	0–72	28	–	2.4 × 102	–	–	57	–	–	43	0.0091
2	0–4	2.0	95	1.9 × 102	6.5	5.2	10	12	12	24	–
	4–8	2.0	39	78	3.0	89	1.8 × 102	1.0	14	28	–
	8–24	15	2.9	44	3.0	4.8	72	ND	ND	–	–
	24–48	20	ND	–	ND	ND	–	ND	ND	–	–
	48–72	15	ND	–	ND	ND	–	ND	ND	–	–
	0–72	54		3.1 × 102	–	–	2.6 × 102	–	–	52	0.015
3	0–4	0.50	5.4 × 103	2.7 × 103	50	1.4 × 102	70	8.1	1.0 × 102	50	–
	4–8	2.0	2.2 × 103	4.4 × 103	3.2	2.2 × 102	4.4 × 102	1.5	33	66	–
	8–24	10	6.8 × 102	6.8 × 103	ND	86	8.6 × 102	ND	4.2	42	–
	24–48	8.0	83	6.6 × 102	ND	11	88	ND	ND	–	–
	48–72	9.0	90	8.1 × 102	ND	0.71	6.4	ND	ND	–	–
	0–72	30	–	1.5 × 104	–	–	1.5 × 103	–	–	1.6 × 102	0.42
Average	0–72	37	–	1.6 × 104	–	–	6.1 × 103	–	–	85	0.15

ND not detected

^aConcentration

^bAbsolute amount