Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 18;10:1067467. doi: 10.3389/fbioe.2022.1067467

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Schulz, Schall, Stehle, Breitmeyer, Krysenko, Mitulski and Wohlleben.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of the FK506 biosynthesis in S. tsukubaensis (modified after Ordóñez-Robles et al., 2018). Arrows in the upper part: three PKS genes (fkbA, fkbB, fkbC) and the NRPS gene (fkbP) of the biosynthetic cluster. Boxes M1 to M10: Modules of the PKSs; circles are domains in the modules: ACP, acyl carrier protein; AT, acyltransferase; ER, enoyl reductase; CAS, CoA synthetase; KR, 3-oxoacyl (ACP) reductase; DH, 3-oxoacyl thioester dehydratase; KS, 3-oxoacyl (ACP) synthase. DHCHC: (4R, 5R)-4,5-dihydroxycyclohex-1-enecarboxylic acid.