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. 2022 Nov 18;10:1067467. doi: 10.3389/fbioe.2022.1067467

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Copyright © 2022 Schulz, Schall, Stehle, Breitmeyer, Krysenko, Mitulski and Wohlleben.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the FK506 production of the wild type and the overexpression strains with optimized lysine supply. Y-axis on right: percentage representation of production optimization; as 100% the FK506 production of the wild type (WT) was set at the respective time. Y-axis on left: calculation of the mean of specific FK506 production over a fermentation period of 6 days. pRM4 stays for the integrative plasmid without an inserted gene. pRM4/–integration of an additional copy of the gene on the integrative plasmid pRM4 encoding: askSt–aspartate kinase; dapASt - dihydropicolinate synthase; askSt*—feedback insensitive aspartate kinase; lysCCg*—deregulated aspartate kinase from C. glutamicum.