TABLE 4.
Dropout model based on phase 3 data.
| Parameter | Description | Estimate (RSE%) |
|---|---|---|
| β0, TRT | Baseline hazard constant in BUP-XR groups | 0.00459 (17) |
| β0, PBO | Baseline hazard constant in PBO group | 0.0102 (35) |
| β1, TRT 2 | Coefficient for craving = 1–5 (category 2) in BUP-XR groups | 0.869 (23) |
| β1, TRT 3 | Coefficient for craving = 6–20 (category 3) in BUP-XR groups | 1.29 (28) |
| β1, TRT 4 | Coefficient for craving > 20 (category 4) in BUP-XR groups | 2.60 (26) |
| β1, PBO 2 | Coefficient for craving = 1–5 (category 2) in PBO group | 0.472 (37) |
| β1, PBO 3 | Coefficient for craving = 6–20 (category 3) in PBO group | 0.534 (43) |
| β1, PBO 4 | Coefficient for craving > 20 (category 4) in PBO group | 1.72 (32) |
| β2 | Coefficient for race (African Americans) on baseline hazard (common to PBO and BUP-XR groups) | 0.602 (19) |
| β3, PBO | Coefficient for age (power model) on baseline hazard in PBO group only | −1.64 (27) |
| β4, PBO | Coefficient for CGI-S ≤ 3 on baseline hazard in PBO group only | 3.86 (27) |
| ke TRT | Rate constant for exponential decrease in hazard over time (Gompertz model) in BUP-XR groups | 0.00763 (22) |
| ke PBO | Rate constant for exponential decrease in hazard over time (Gompertz model) in PBO group | 0.00895 (37) |
CGI-S, Clinical Global Impression-Severity scale; PBO, placebo; RSE, relative standard error.