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. 2022 Nov 18;13:1070940. doi: 10.3389/fmicb.2022.1070940

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Copyright © 2022 Lin, Zheng, Li, Wang, Wei, Xie, Lu, Tian, Wang, Qu and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of SARS-CoV-2 variants using smartphone-controlled CALIBURN-v2. (A) Overall sensitivity of CALIBURN-v2 on clinical nucleic acid specimens of SARS-CoV-2 variants. (B) Sensitivity of CALIBURN-v2 on different SARS-CoV-2 variants and the correlations with RT-qPCR Ct values. The ratios of positive samples with each variants are indicated. Ct values are obtained from the RT-qPCR assay for SARS-CoV-2 N gene. NTC, non-template control. (C) Concordance between RT-qPCR and CALIBURN-v2 for SARS-CoV-2 variant detection. PPA, positive predictive agreement; NPA, negative predictive agreement; CI, confidence interval.