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. 2022 Dec 1;13:7408. doi: 10.1038/s41467-022-35069-9

Fig. 4. Gpr151 regulates hepatic gluconeogenesis in a cell-autonomous manner.

Fig. 4

a Blood glucose levels measured during pyruvate tolerance testing (PTT) in male DIO WT and KO mice. AOC compared using two-tailed Student’s t test (N = 14, WT; N = 9, KO). b Blood lactate levels during PTT in male DIO WT and KO mice. AOC compared using two-tailed Student’s t test (N = 5, WT; N = 6, KO). c Quantification of glucagon levels in blood plasma of fasted 16-week-old DIO mice by ELISA. Two-tailed Student’s t test (N = 6, WT; N = 7, KO). d RT-qPCR quantification of glucagon receptor (Gcgr) gene expression in the livers from Gpr151 WT and KO DIO male mice. Two-tailed Student’s t test (N = 5, WT; N = 5, KO). e Quantification of media glucose produced by Gpr151 WT and KO primary hepatocytes ex vivo, normalized by protein concentration. Results of one experiment representative for three independent experiments. Ordinary one-way ANOVA with Sidak’s multiple comparisons test (pval < 0.0001). n = 3 technical replicates. a–e All data are presented as mean values ±SEM. Source data are provided as a Source Data file.