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. 2022 Dec 1;12:20781. doi: 10.1038/s41598-022-25356-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Risk score is closely related to tumor immune environment characteristics and immune infiltration in HCC. (A,B) Heat map (using “pheatmap” R package, https://cran.r-project.org/bin/windows/base/old/4.1.3/) distribution of risk score and various immune scores. (C–F) Comparison of estimate score, stromal score, immune score, and tumor purity between high-risk groups and low-risk groups. (G) The relationship between immune function and risk score in TCGA cohort. (H) The relationship between immune cell infiltration and risk score in the TCGA cohort. (I–N) Association between this signature and B cells, CD4 + T cells, CD8 + T cells, dendritic cells, macrophages cells and neutrophil cells.