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. 2022 Dec 1;13:7419. doi: 10.1038/s41467-022-35094-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Results of mapping spatial data to single-cell data using the optimal transport plan. Spatial scatter pie plot displays the well-structured cluster composition in adult mouse brain anterior slice. b Lists of canonical cerebral cortical neuron types with scaled proportion. c Spatial deconvolution result of the HER2-positive breast cancer. d Proportion of typical clusters in tumor microenvironment. e Expression of marker genes corresponding to clusters in d. f Tertiary Lymphoid Structure (TLS) scores inferred from summing the proportion of T cells and B cells together with their colocalization.