Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 28;32(12):1047–1067. doi: 10.1038/s41422-022-00736-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Top panel, pie charts of clinical indicators. Bottom panel, sample numbers and multi-omics datasets of the cohort. b Genomic profile and associated clinical features of patients with PitNETs. SMGs in this dataset identified by MutSigCV and OncodriveCLUST (q value < 0.1) are shown. Right panel, percentage of samples affected. Top panel, number of mutations per sample. Middle panel, distribution of significant mutations across sequenced samples, color coded by mutation type. Bottom panel, percentage of somatic base changes per sample. c Comparison of the TMB of our PitNETs cohort and 33 cancer types in TCGA studies. d Boxplot showing the VAF of the top 20 SMGs. e Bar plot showing the genes with significantly different mutation frequencies based on Fisher’s exact test by clinicopathological subtype (Fisher’s exact test, P value < 0.01). The numbers listed on the right side of the barplot represented the mutation frequencies in the indicated clinicopathological subtype tumors. The numbers listed on the left side of the barplot represented the mutation frequencies in the rest tumors. f, g Arm-level and focal-level amplifications and deletions. GISTIC analysis was performed to determine significant regions and genes included in the recurrent CNAs identified in patients with PitNETs. h PCA analysis of proteomics data from 200 PitNETs and 7 APGs based on clinicopathological subtypes.