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. 2022 Nov 18;16:1008752. doi: 10.3389/fnins.2022.1008752

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Copyright © 2022 Liu, Wan, Shi and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flowchart of the study. Microarray data from whole peripheral blood of patients with Alzheimer’s disease (AD) or ischemic stroke (IS) were obtained and analysis for differentially expressed genes (DEGs) between patients and healthy controls was performed. Protein-protein interactions network (PPI–Net), drug targets, functional enrichment, and immune infiltration analysis were applied to common DEGs between AD and IS, to explore shared mechanism between these two diseases. Hub genes obtained by PPI-Net analysis and potential drug targets were validated with test dataset of AD and IS.