Table 2.
Mendelian randomization estimates for the associations of genetically predicted sleep traits with cardiac diseases in UK Biobank
| Exposure | Method | Outcome | |||||||
|---|---|---|---|---|---|---|---|---|---|
| IHD | HF | MI | AF | ||||||
| SNPs | Odds ratio (95% CI) | SNPs | Odds ratio (95% CI) | SNPs | Odds ratio (95% CI) | SNPs | Odds ratio (95% CI) | ||
| Sleep duration | IVW | 59 | 0.9997 (0.9995–0.9998) | 59 | 0.9999 (0.9999–1.0000) | 59 | 0.9999 (0.9998–1.0000) | 58 | 0.9999 (0.9998–0.9999) |
| MR‐PRESSO | 0.9997 (0.9995–0.9998) | 0.9999 (0.9999–1.0000) | 0.9999 (0.9998–1.0000) | 0.9999 (0.9998–0.9999) | |||||
| Short sleep | IVW | 23 | 1.0094 (0.9983–1.0206) | 23 | 1.0012 (0.9988–1.0036) | 23 | 1.004 (0.9989–1.0091) | 22 | 1.0006 (0.997–1.0043) |
| MR‐PRESSO | 1.0099 (0.9995–1.0204) | 1.001 (0.9986–1.0034) | 1.004 (0.9993–1.0088) | 1.0011 (0.9976–1.0046) | |||||
| Long sleep | IVW | 7 | 0.9944 (0.9866–1.0023) | 7 | 0.9994 (0.9971–1.0018) | 7 | 0.9971 (0.991–1.0031) | 6 | 0.9955 (0.9919–0.9992) |
| MR‐PRESSO | 0.9944 (0.9872–1.0017) | 0.9994 (0.9971–1.0018) | 0.9971 (0.991–1.0031) | 0.9955 (0.9929–0.9982) | |||||
| Chronotype | IVW | 111 | 1.0005 (0.9934–1.0077) | 111 | 0.9993 (0.9978–1.0008) | 111 | 0.9992 (0.9957–1.0026) | 101 | 0.9984 (0.9957–1.0012) |
| MR‐PRESSO | 1.0007 (0.9937–1.0077) | 0.9992 (0.9977–1.0006) | 0.9993 (0.9959–1.0027) | 0.9987 (0.996–1.0014) | |||||
| Insomnia | IVW | 35 | 1.0117 (1.0051–1.0183) | 35 | 1.0005 (0.999–1.0021) | 35 | 1.0049 (1.0019–1.0079) | 33 | 1.0007 (0.9986–1.0029) |
| MR‐PRESSO | 1.0129 (1.0064–1.0195) | 1.0008 (0.9993–1.0024) | 1.0053 (1.0024–1.0081) | 1.0007 (0.9987–1.0028) | |||||
IVW, inverse variance weighted; MR‐PRESSO, MR pleiotropy residual sum and outlier; IHD, ischaemic heart disease; HF, heart failure; MI, myocardial infarction; AF, atrial fibrillation; CI, confidence intervals; SNPs, the number of single nucleotide polymorphisms.