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. 2022 Oct 21;13(23):3420–3430. doi: 10.1111/1759-7714.14693

TABLE 1.

The grades of CIP based on clinical manifestations and radiological findings

Grades Clinical manifestations Radiological findings
Grade 1 Asymptomatic One lobe of the lung or <25% of the lung parenchyma
Grade 2 New respiratory symptoms, or aggravation of existing symptoms such as shortness of breath, cough, chest pain, fever, and increased oxygen requirements Lesions affect 25%–50% of the lung parenchyma
Grade 3 Severe symptoms, limited daily activities Lesions affect all lung lobes or >50% of the lung parenchyma
Grade 4 Life‐threatening respiratory damage

Abbreviation: CIP, checkpoint inhibitor pneumonia.