Table 4.
Change in echocardiographic parameters at 6 months, in relation to the Sac/Val dosage
| Δ‐Change in echocardiography a | Maximum dose not reached, n = 59 | Maximum dose reached, n = 36 | P |
|---|---|---|---|
| ΔLVEDV, mL | −9 [−32.6; 11] | −20 [−32; −5] | 0.054 |
| ΔLVESV, mL | −15.6 [−38; −6] | −25.5 [−33.7; −13.5] | 0.037 |
| ΔLVgLS, % | −1.5 [−2.9; −0.6] | −2 [−2.7; −1.1] | 0.2 |
| ΔLVEF, % | 5 [3–9.4] | 7.75 [5.25–11] | 0.032 |
| ΔE/e′ ratio | −2 [−4; 0] | −2.4 [−5; −1.1] | 0.13 |
| ΔBasal RVD, mm | −2 [−3; 0.5] | −1 [−3; 0] | 0.72 |
| ΔRVgLS, % | −1 [−3.6; −0.27] | −1.9 [−2.9; −0.95] | 0.52 |
| ΔRV‐FW‐LS, % | −1 [−4.6; −0.07] | −2 [−3.4; −0.5] | 0.22 |
| ΔFAC, % | 4 [2–5] | 4.75 [2–6] | 0.27 |
| ΔTAPSE, mm | 1 [0.5–2.5] | 2 [1–3] | 0.2 |
| ΔRVs', cm/s | 1 [0.35–2] | 1.5 [1–3] | 0.05 |
| ΔsPAP, mmHg | −5 [−13.5; 1.25] | −5 [−10; 0] | 0.57 |
LVEDV, left ventricle end‐diastolic volume; LVESV, left ventricle end‐systolic volume; LVgLS, left ventricular global longitudinal strain; LVEF, left ventricular ejection fraction; E, early‐wave transmitral diastolic velocity; e′, early‐diastolic velocity at tissue Doppler imaging; RVD, right ventricle diameter; RVgLS, right ventricular global longitudinal strain; RV‐FW‐LS, right ventricular free wall longitudinal strain; FAC, fractional area change; TAPSE, tricuspid annular plane systolic excursion; RVs′, tricuspid annular S′ velocity; sPAP, pulmonary artery systolic pressure. We have reported in bold the statistically significant P‐value.
Δ‐Change in echocardiography: follow‐up ‐ baseline value.