Table 3.
Association of serum miRNAs per 1 SD increase with the composite of heart failure hospitalizations or cardiovascular death during follow‐up among patients with myocardial infarction
| HR per 1 SD increase (95% CI) | P value | C‐statistic (95% CI) | Increase in C‐statistic (95% CI) | |
|---|---|---|---|---|
| miR‐20a‐5p a | 1.03 (0.77–1.38) | 0.827 | n/a | n/a |
| Model 2 | 1.07 (0.80–1.43) | 0.656 | n/a | n/a |
| Model 3 | 1.04 (0.77–1.40) | 0.815 | n/a | n/a |
| Model 4 | 1.26 (0.94–1.70) | 0.117 | n/a | n/a |
| Model 5 | 1.01 (0.78–1.32) | 0.920 | n/a | n/a |
| Model 6 | 1.01 (0.77–1.33) | 0.933 | n/a | n/a |
| miR‐21‐5p a | 2.00 (1.52–2.63) | 0.000 | 0.7828 (0.7141–0.8517) | 0.0517 (0.0011–0.1024) |
| Model 2 | 2.07 (1.56–2.74) | 0.000 | 0.7928 (0.7147–0.8709) | 0.0565 (0.0022–0.1109) |
| Model 3 | 1.87 (1.41–2.48) | 0.000 | 0.7962 (0.7258–0.8666) | 0.0376 (0–0.0807) |
| Model 4 | 1.82 (1.36–2.46) | 0.000 | 0.8403 (0.7618–0.9188) | 0.0143 (0–0.0393) |
| Model 5 | 1.52 (1.13–2.04) | 0.005 | 0.8110 (0.7389–0.8830) | 0.0181 (0–0.0458) |
| Model 6 | 1.42 (1.05–1.93) | 0.022 | 0.8316 (0.7677–0.8954) | 0.0104 (0–0.0296) |
| miR‐23a‐3p a | 2.11 (1.53–2.90) | 0.000 | 0.7909 (0.7246–0.8572) | 0.0598 (0.0135–0.1061) |
| Model 2 | 2.17 (1.56–3.01) | 0.000 | 0.7991 (0.7233–0.8749) | 0.0628 (0.0111–0.1145) |
| Model 3 | 2.00 (1.43–2.79) | 0.000 | 0.7969 (0.7323–0.8616) | 0.0383 (0–0.0827) |
| Model 4 | 1.89 (1.33–2.70) | 0.000 | 0.8529 (0.7934–0.9124) | 0.0270 (0–0.0584) |
| Model 5 | 1.59 (1.16–2.18) | 0.004 | 0.8233 (0.7619–0.8848) | 0.0305 (0–0.0653) |
| Model 6 | 1.50 (1.09–2.06) | 0.013 | 0.8410 (0.7842–0.8978) | 0.0198 (0–0.0501) |
| miR‐27b‐3p a | 1.79 (1.21–2.65) | 0.004 | 0.7562 (0.6612–0.8512) | 0.0251 (0–0.0663) |
| Model 2 | 1.75 (1.18–2.59) | 0.005 | 0.7618 (0.6618–0.8618) | 0.0255 (0–0.0637) |
| Model 3 | 1.52 (1.01–2.28) | 0.043 | 0.7648 (0.6781–0.8514) | 0.0061 (0–0.0358) |
| Model 4 | 2.20 (1.39–3.48) | 0.001 | 0.8300 (0.7555–0.9044) | 0.0040 (0–0.0437) |
| Model 5 | 1.37 (0.97–1.95) | 0.075 | 0.8024 (0.7192–0.8857) | 0.0096 (0–0.0355) |
| Model 6 | 1.40 (0.99–2.00) | 0.059 | 0.8252 (0.7482–0.9021) | 0.0040 (0–0.0274) |
| miR‐30b‐5p a | 1.22 (0.87–1.73) | 0.251 | n/a | n/a |
| Model 2 | 1.25 (0.87–1.77) | 0.226 | n/a | n/a |
| Model 3 | 1.18 (0.84–1.67) | 0.342 | n/a | n/a |
| Model 4 | 1.46 (1.00–2.15) | 0.051 | n/a | n/a |
| Model 5 | 1.16 (0.85–1.58) | 0.351 | n/a | n/a |
| Model 6 | 1.13 (0.81–1.57) | 0.471 | n/a | n/a |
| miR‐106b‐5p a | 1.16 (0.87–1.55) | 0.319 | n/a | n/a |
| Model 2 | 1.19 (0.88–1.61) | 0.271 | n/a | n/a |
| Model 3 | 1.17 (0.87–1.56) | 0.294 | n/a | n/a |
| Model 4 | 1.39 (1.01–1.91) | 0.043 | n/a | n/a |
| Model 5 | 1.09 (0.85–1.41) | 0.491 | n/a | n/a |
| Model 6 | 1.06 (0.80–1.40) | 0.694 | n/a | n/a |
| miR‐107 a | 1.39 (0.94–2.05) | 0.098 | n/a | n/a |
| Model 2 | 1.46 (0.97–2.18) | 0.067 | n/a | n/a |
| Model 3 | 1.45 (0.98–2.15) | 0.062 | n/a | n/a |
| Model 4 | 1.48 (0.93–2.37) | 0.097 | n/a | n/a |
| Model 5 | 1.42 (0.96–2.10) | 0.081 | n/a | n/a |
| Model 6 | 1.28 (0.87–1.90) | 0.213 | n/a | n/a |
| miR‐122‐5p a | 1.80 (1.30–2.48) | 0.000 | 0.7427 (0.6528–0.8325) | 0.0115 (0–0.0579) |
| Model 2 | 1.81 (1.30–2.51) | 0.000 | 0.7589 (0.6655–0.8523) | 0.0226 (0–0.0722) |
| Model 3 | 1.70 (1.26–2.30) | 0.001 | 0.7747 (0.6888–0.8606) | 0.0161 (0–0.0544) |
| Model 4 | 1.64 (1.21–2.22) | 0.001 | 0.8236 (0.7474–0.8998) | 0.0024 (0–0.0186) |
| Model 5 | 1.31 (0.96–1.78) | 0.087 | 0.7880 (0.7096–0.8663) | 0.0049 (0–0.0105) |
| Model 6 | 1.30 (0.94–1.79) | 0.116 | 0.8181 (0.7437–0.8925) | 0.0031 (0–0.0107) |
| miR‐148b‐3p a | 1.14 (0.84–1.55) | 0.402 | n/a | n/a |
| Model 2 | 1.15 (0.85–1.56) | 0.363 | n/a | n/a |
| Model 3 | 1.16 (0.85–1.57) | 0.345 | n/a | n/a |
| Model 4 | 1.42 (0.98–2.06) | 0.650 | n/a | n/a |
| Model 5 | 1.03 (0.77–1.38) | 0.845 | n/a | n/a |
| Model 6 | 1.15 (0.83–1.60) | 0.409 | n/a | n/a |
| miR‐210‐3p a | 2.65 (1.92–3.64) | 0.000 | 0.8026 (0.7319–0.8732) | 0.0714 (0.0068–0.1360) |
| Model 2 | 2.70 (1.95–3.73) | 0.000 | 0.8050 (0.7194–0.8906) | 0.0687 (0–0.1420) |
| Model 3 | 2.42 (1.75–3.34) | 0.000 | 0.8079 (0.7322–0.8835) | 0.0492 (0–0.1074) |
| Model 4 | 2.21 (1.57–3.12) | 0.000 | 0.8443 (0.7742–0.9143) | 0.0183 (0–0.0511) |
| Model 5 | 1.88 (1.32–2.67) | 0.000 | 0.8257 (0.7579–0.8935) | 0.0329 (0–0.0793) |
| Model 6 | 1.84 (1.30–2.59) | 0.001 | 0.8432 (0.7743–0.9121) | 0.0220 (0–0.0562) |
| miR‐221‐3p a | 2.03 (1.47–2.80) | 0.000 | 0.7809 (0.7091–0.8526) | 0.0497 (0–0.1039) |
| Model 2 | 2.04 (1.45–2.86) | 0.000 | 0.7864 (0.7046–0.8682) | 0.0501 (0–0.1115) |
| Model 3 | 1.92 (1.40–2.64) | 0.000 | 0.7991 (0.7227–0.8756) | 0.0405 (0–0.0879) |
| Model 4 | 2.13 (1.45–3.13) | 0.000 | 0.8663 (0.8107–0.9219) | 0.0403 (0–0.0852) |
| Model 5 | 1.70 (1.23–2.37) | 0.001 | 0.8231 (0.7598–0.8864) | 0.0303 (0–0.0683) |
| Model 6 | 1.58 (1.14–2.19) | 0.006 | 0.8498 (0.7896–0.9101) | 0.0286 (0–0.0632) |
CI, confidence interval; HR, hazard ratio; n/a, not applicable; SD, standard deviation.
Model 2: adjusted for age, sex, hypertension, smoking status, diabetes, dyslipidaemia, and history of MI. Model 3: adjusted for age, sex, and log (troponin I). Model 4: adjusted for age, sex, and log (NT‐proBNP). Model 5: adjusted for age, sex, and GRACE risk score. Model 6: adjusted for age, sex, left ventricular ejection fraction (LVEF), and Killip class. P values presented are corrected for multiple comparisons (number of miRNAs) using the Benjamini and Hochberg correction. HRs and 95% CIs are presented without correction.
a
Age and sex adjusted.