Table 1.
Patient characteristics at the time of ATTRwt diagnosis stratified by worsening heart failure within the following 12 months
| Variable | All (n = 104) | No. of HF admission (n = 68) | HF admission (n = 36) | P‐value |
|---|---|---|---|---|
| Age (years), mean ± SD | 81.2 ± 6 | 80.7 ± 6 | 82.0 ± 6 | 0.33 |
| Male gender, % | 90 (n = 94) | 91 (n = 62) | 92 (n = 33) | 0.93 |
| BSA (m2), mean ± SD | 1.95 ± 0.17 | 1.97 ± 0.18 | 1.91 ± 0.14 | 0.06 |
| NYHA, I/II/III/IV, % | 26/47/26/1 | 25/49/25/1 | 28/44/28/0 | 0.86 |
| Hypertension, % | 64 (n = 67) | 65 (n = 44) | 64 (n = 23) | 0.93 |
| IHD, % | 23 (n = 24) | 18 (n = 12) | 33 (n = 12) | 0.07 |
| Diabetes, % | 15 (n = 16) | 15 (n = 10) | 17 (n = 6) | 0.79 |
| Aortic stenosis, % | 24 (n = 25) | 24 (n = 16) | 25 (n = 9) | 0.87 |
| Pacemaker device, % | 35 (n = 36) | 26 (n = 18) | 50 (n = 18) | 0.02 |
| Carpal tunnel syndrome, % | 38 (n = 40) | 40 (n = 27) | 36 (n = 13) | 0.72 |
| Spinal stenosis, % | 7 (n = 7) | 4 (n = 3) | 11 (n = 4) | 0.20 |
| Diuretics, % | 77 (n = 79) | 71 (n = 49) | 83 (n = 30) | 0.15 |
| ACE/ARB, % | 45 (n = 47) | 46 (n = 31) | 44 (n = 16) | 0.91 |
| Beta blockers, % | 44 (n = 45) | 40 (n = 27) | 47 (n = 17) | 0.46 |
| Anti‐coagulation, % | 62 (n = 64) | 57 (n = 39) | 69 (n = 25) | 0.16 |
| Heart rate (beats/min), mean ± SD | 73 ± 15 | 72 ± 13 | 74 ± 19 | 0.69 |
| SBP (mmHG), mean ± SD | 134 ± 18 | 137 ± 19 | 130 ± 14 | 0.07 |
| DBP (mmHG), mean ± SD | 80 ± 12 | 81 ± 12 | 79 ± 11 | 0.69 |
| Troponin T (ng/L), median (IQR) | 63 (56) | 58 (60) | 76 (69) | 0.10 |
| NT‐proBNP (ng/L), median (IQR) | 2544 (3794) | 2116 (3407) | 3665 (7237) | 0.01 |
| eGFR (mL/min), mean ± SD | 62 ± 19 | 64 ± 19 | 57 ± 19 | 0.08 |
| Sinus rhythm, % | 55 (n = 57) | 59 (n = 40) | 47 (n = 17) | 0.26 |
| Atrial fibrillation, % | 41 (n = 43) | 37 (n = 25) | 50 (n = 18) | 0.19 |
| Low voltage, % | 27 (n = 28) | 25 (n = 17) | 31 (n = 11) | 0.54 |
| 1st deg. AV block, % | 15 (n = 15) | 15 (n = 10) | 14 (n = 5) | 0.91 |
| Left bundle branch block, % | 21 (n = 22) | 19 (n = 13) | 25 (n = 9) | 0.49 |
| Pseudo‐infarction, % | 8 (n = 8) | 7 (n = 5) | 8 (n = 3) | 0.86 |
AV, atrioventricular; BSA, body surface area; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HF, heart failure; IHD, ischaemic heart disease; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; SBP, systolic blood pressure.