Table 4.
Clinical and echocardiographic characteristics of patients with or without PMI at the time of ATTRwt diagnosis
| Variable | No. of PM (n = 68) | PM (n = 36) | P‐value |
|---|---|---|---|
| Age (years), mean ± SD | 81.6 ± 7 | 80.4 ± 6 | 0.39 |
| NYHA I/II/III/IV (%) | 28/41/29/1 | 22/58/19/0 | 0.36 |
| Atrial fibrillation, n (%) | 31 (46) | 12 (33) | 0.23 |
| eGFR (mL/min), mean ± SD | 64.4 ± 18 | 56.3 ± 20 | 0.04 |
| NT‐proBNP (ng/L), median (IQR) | 2225 (3494) | 2839 (3506) | 0.04 |
| LVEF (%), mean ± SD | 48 ± 11 | 38 ± 12 | <0.01 |
| LV‐GLS (%), mean ± SD | −11.4 ± 4 | −8.9 ± 3 | <0.01 |
| LV‐GWI (mmHg%), mean ± SD | 1,165 ± 437 | 825 ± 343 | <0.01 |
| LVMI (g/m2), mean ± SD | 151 ± 34 | 183 ± 44 | <0.01 |
| LAVi (mL/m2), median (IQR) | 30 (16) | 29 (16) | 0.92 |
| RAVi (mL/m2), median (IQR) | 35 (22) | 43 (17) | 0.04 |
| RV free wall thickness (mm), mean ± SD | 5.8 (3.5) | 7.0 (3.5) | 0.11 |
| TAPSE (mm), mean ± SD | 19 ± 5 | 15 ± 6 | 0.01 |
| TRG (mmHg), mean ± SD | 28 ± 8 | 30 ± 12 | 0.38 |
LAVi, left atrial volume index; LVEF, left ventricular ejection fraction; LV‐GLS, left ventricular global longitudinal strain; LV‐GWI, left ventricular global work index; LVMI, left ventricular mass index; PM, pacemaker; RAVi, right atrial volume index; TAPSE, tricuspid annular plane systolic excursion; TRG, tricuspid return gradient.