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. 2022 Nov 17;13:1059376. doi: 10.3389/fimmu.2022.1059376

Table 1.

Updated ADAM17 substrates (7, 32).

Cytokines Growth factors Receptors Adhesion molecules Others
CSF1 (93) AREG (17) 4-1BB/CD137 (94) ALCAM/CD166 (95, 96) EGFRL (97)
CX3CL1 (98) Epigen (99) ACE2 (100, 101) CD44 (102, 103) Glycocalyx (104)
FLT-3L (105) Epiregulin (106) APP (107) CD62L/L-selectin (108) Klotho (109)
INFγ (110) HB-EGF (111) CA IX (112) Collagen XVII (113115) Pref1 (116, 117)
Jagged1 (118) HPP1/TMEFF2/Tomoegulin2 (119) CD163 (75) Desmoglein2 (95, 120) SEMA4D (121)
Kit-ligand l and 2 (122) NRG1 (10) CD30 (123) E-cadherin (124) VASN/Vasorin (125)
LAG-3 (126) TGFα (127) CD40 (128, 129) EpCAM (130)
MICA (131) CD89/FcαR (132) ICAM1 (133)
MICB (134) c-MET (38, 135) L1-CAM (136)
RANKL (7, 137) EMMPRIN/CD147 (138) NCAM (139)
TNFα (140) EPCR (141) Nectin4 (142)
TNFβ (143) ErbB4 (96) PTP-LAR (144)
GHR (145) VCAM1 (146)
GPIbα (6)
GPV (147)
GPVI (148)
IGFR1 (138)
IGF2R (149)
IL-11R (5)
IL-1RII (150, 151)
IL-6R (152, 153)
Integrin β1 (154, 155)
JAM-A/FIIR (156)
KIM1 (157)
LeptinR (158)
LOX1 (159, 160)
LRP1 (46, 161)
MEGF10 (162)
MerTK (163)
Notch1 (164)
NPR (32, 165)
p55TNFαR1 (140)
P75 (11)
p75 TNFR (127)
Ptprz (166)
PTPRA/PTPα (167)
sVLDLR (4)
Syndecan-1 and -4 (168)
TGFβR1 (169)
TIL4 (170)
TIM-3 (171, 172)
TNFR1 (173)
Trop2 (174, 175)
VEGFR2 (176)
VPS10P (177)