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. 2022 Nov 18;10:965204. doi: 10.3389/fped.2022.965204

Table 3.

Most relevant studies characterizing myocardial fibrosis in patients with arterial switch operation.

Reference Year Population Characterization of fibrosis Key clinical findings
CMR with LGE Shepard, et al. (115) 2016 220 patients (mean age of 15.4 years) Myocardial scarring characterized by LGE was found in only 1.8% of patients. LGE was not common even when 26% of patients had some degree of left ventricular dilatation and 21.5% of patients had some degree of left ventricular dysfunction.
CMR with ECV Grotenhuis, et al. (116) 2019 30 patients (mean age 15.4 years) No LGE was found.
LV native T1 times were prolonged in ASO patients and correlated with the LV mass/volume ratio.
No differences were found in ECV.
Neither ECV nor T1 times correlated with LV function.
Suther, et al. (117) 2019 30 patients (mean age 11.7 years) No LGE was found.
Slight increase in ECV compared with healthy controls in all coronary territories