Table 3.
Most relevant studies characterizing myocardial fibrosis in patients with arterial switch operation.
| Reference | Year | Population | Characterization of fibrosis | Key clinical findings | |
|---|---|---|---|---|---|
| CMR with LGE | Shepard, et al. (115) | 2016 | 220 patients (mean age of 15.4 years) | Myocardial scarring characterized by LGE was found in only 1.8% of patients. | LGE was not common even when 26% of patients had some degree of left ventricular dilatation and 21.5% of patients had some degree of left ventricular dysfunction. |
| CMR with ECV | Grotenhuis, et al. (116) | 2019 | 30 patients (mean age 15.4 years) | No LGE was found. LV native T1 times were prolonged in ASO patients and correlated with the LV mass/volume ratio. No differences were found in ECV. |
Neither ECV nor T1 times correlated with LV function. |
| Suther, et al. (117) | 2019 | 30 patients (mean age 11.7 years) | No LGE was found. Slight increase in ECV compared with healthy controls in all coronary territories |