Table 2.
Cerebral nuclei volumes of each group and P value of group comparisons.
| Mean (SD; mm3) | Uncorrected P value | PFDR value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nuclei | Control | OB | PWS | A | B | C | A | B | C | ||
| thalamus_L | 6,070 (590) | 6,496 (919) | 5,274 (904) | 0.134 | 0.022 | 0.219 | 0.248 | 0.052 | 0.352 | ||
| thalamus_R | 6,048 (582) | 6,458 (919) | 5,274 (890) | 0.139 | 0.023 | 0.226 | 0.248 | 0.052 | 0.352 | ||
| caudate_L | 2,868 (368) | 2,989 (431) | 2,603 (471) | 0.225 | 0.122 | 0.334 | 0.248 | 0.131 | 0.390 | ||
| caudate_L | 3,067 (412) | 3,141 (471) | 2,567 (486) | 0.093 | 0.055 | 0.406 | 0.248 | 0.086 | 0.406 | ||
| putamen_L | 3,674 (461) | 4,120 (827) | 3,484 (643) | 0.374 | 0.073 | 0.174 | 0.374 | 0.102 | 0.352 | ||
| putamen_R | 3,871 (480) | 4,012 (794) | 3,390 (683) | 0.207 | 0.088 | 0.380 | 0.248 | 0.110 | 0.406 | ||
| pallidum_L | 1,281 (129) | 1,388 (213) | 1,121 (212) | 0.170 | 0.026 | 0.194 | 0.248 | 0.052 | 0.352 | ||
| pallidum_R | 1,281 (144) | 1,393 (223) | 1,149 (201) | 0.216 | 0.039 | 0.201 | 0.248 | 0.068 | 0.352 | ||
| hippocampus_L | 2,513 (348) | 2,782 (557) | 2,073 (429) | 0.136 | 0.013 | 0.207 | 0.248 | 0.046 | 0.352 | ||
| hippocampus_R | 2,448 (397) | 2,948 (487) | 2,094 (501) | 0.180 | 0.010 | 0.058 | 0.248 | 0.046 | 0.352 | ||
| amygdala_L | 815 (95) | 852 (128) | 746 (108) | 0.230 | 0.094 | 0.322 | 0.248 | 0.110 | 0.390 | ||
| amygdala_R | 844 (70) | 784 (84) | 644 (88) | 0.003 | 0.261 | 0.203 | 0.042 | 0.261 | 0.352 | ||
| NAc_L | 377 (72) | 449 (78) | 293 (61) | 0.070 | 0.003 | 0.088 | 0.248 | 0.042 | 0.352 | ||
| NAc_R | 360 (64) | 387 (77) | 268 (50) | 0.044 | 0.008 | 0.295 | 0.248 | 0.046 | 0.390 | ||
SD, standard deviation; PFDR, P value after FDR correction; PWS, children with Prader-Willi Syndrome; OB, obese children without PWS; NAc, nucleus accumbens; L, left; R, right. Bold, PFDR < 0.05. A: Comparison between the PWS and control groups (PWS vs. control). B: Comparison between the PWS and OB groups (PWS vs. OB). C: Comparison between the OB and control groups (OB vs. control).