Table 3.
Hypothalamic subunit volumes of each group and P value of group comparisons.
| Mean (SD; mm3) | Uncorrected P value | PFDR value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Subunits | Control | OB | PWS | A | B | C | A | B | C | ||
| a-iHyp_L | 10.1 (2.9) | 10.6 (2.4) | 5.8 (2.7) | 0.012 | 0.011 | 0.320 | 0.022 | 0.022 | 0.494 | ||
| a-iHyp_R | 7.7 (2.4) | 8.0 (1.4) | 7.7 (1.9) | 0.415 | 0.406 | 0.243 | 0.415 | 0.406 | 0.494 | ||
| a-sHyp_L | 12.0 (3.3) | 12.6 (2.8) | 9.9 (1.0) | 0.153 | 0.070 | 0.468 | 0.200 | 0.105 | 0.494 | ||
| a-sHyp_R | 14.3 (3.7) | 14.4 (3.9) | 13.4 (2.3) | 0.350 | 0.358 | 0.494 | 0.382 | 0.391 | 0.494 | ||
| posHyp_L | 103.5 (10.3) | 102.2 (8.2) | 88.9 (9.3) | 0.011 | 0.013 | 0.434 | 0.022 | 0.022 | 0.494 | ||
| posHyp_R | 99.0 (9.8) | 95.0 (10.3) | 70.8 (12.2) | 0.003 | 0.005 | 0.310 | 0.022 | 0.020 | 0.494 | ||
| infTub_L | 96.7 (16.6) | 109.8 (14.2) | 67.3 (17.1) | 0.013 | 0.001 | 0.161 | 0.022 | 0.012 | 0.494 | ||
| infTub_R | 99.2 (16.5) | 95.6 (12.6) | 60.9 (20.6) | 0.009 | 0.007 | 0.375 | 0.022 | 0.021 | 0.494 | ||
| supTub_L | 89.7 (9.0) | 89.2 (9.8) | 81.0 (10.7) | 0.167 | 0.159 | 0.478 | 0.200 | 0.212 | 0.494 | ||
| supTub_R | 95.9 (8.9) | 86.6 (11.4) | 81.0 (9.0) | 0.024 | 0.216 | 0.139 | 0.036 | 0.259 | 0.494 | ||
| Hyp_L | 311.4 (32.7) | 324.3 (29.1) | 252.9 (35.7) | 0.010 | 0.005 | 0.329 | 0.022 | 0.020 | 0.494 | ||
| Hyp_R | 316.1 (35.4) | 299.1 (30.1) | 233.7 (41.0) | 0.008 | 0.011 | 0.286 | 0.022 | 0.022 | 0.494 | ||
SD, standard deviation; PFDR, P value after FDR correction; PWS, children with Prader-Willi Syndrome; OB, obese children without PWS; a-iHyp, anterior-inferior; a-sHyp, anterior–superior; posHyp, posterior; infTub, inferior tubular; supTub, superior tubular; Hyp, hypothalamus; L, left; R, right. Bold, PFDR < 0.05. A: Comparison between the PWS and control groups (PWS vs. control). B: Comparison between the PWS and OB groups (PWS vs. OB). C: Comparison between the OB and control groups (OB vs. control).