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. 2022 Nov 18;13:1048751. doi: 10.3389/fphys.2022.1048751

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Copyright © 2022 Wang, Lincoln, Nguyen, Li and Young.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of rhythmicity is not caused by differential expression. (A) Flowchart showing the pipeline for differential gene expression (DGE) analysis. Number in each box represents number of genes. (B) Intersection of differentially expressed genes identified by DESeq2 (Benjamini-Hochberg adjusted p < 0.05) in inc ¹ (magenta) and wake ^D2 (green). (C) Intersection of differentially expressed genes identified by edgeR (p < 0.05) in inc ¹ (magenta) and wake ^D2 (green). (D) Enriched biological processes revealed by gene ontology analysis using 403 differentially expressed genes. Top 10 enriched biological pathways are shown. Bars represent number of genes and dots represent p-value. (E) Intersection of differentially expressed genes (orange) and loss of rhythmicity genes (cyan) in both inc ¹ and wake ^D2 animals. The 3 intersected genes are listed.