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. 2022 Oct 31;24(6):737. doi: 10.3892/etm.2022.11673

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Copyright: © Tan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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KLF2 overexpression activities Nrf2 expression and enhances autophagy in ox-LDL-induced HUVECs and THP-1 macrophage derived foam cells. The expression of Nrf2 and autophagy-related proteins in (A) ox-LDL induced HUVECs and (B) THP-1 macrophages transfected with pcDNA3.1-KLF2 was analyzed by western blotting. ^*P<0.05, ^**P<0.01 and ^***P<0.001. KLF2, Krüppel like transcription factor 2; ox-LDL, oxidized low-density lipoprotein; HUVECs, human umbilical vein endothelial cells; NC, negative control.