Table 2.
Baseline metabolic and functional variables by outcome and age
| Variable | Non-progressors | Progressors | pprogr value | page value | pg×a value | ||
|---|---|---|---|---|---|---|---|
| <14 years old | ≥14 years old | <14 years old | ≥14 years old | ||||
| n | 264 | 167 | 184 | 43 | |||
| Fasting glucose, mmol/l | 5.1 (0.6) | 5.1 (0.6) | 5.1 (0.6) | 5.1 (0.7) | NS | NS | NS |
| Fasting C-peptide, pmol/l | 248 (198) | 397 (148) | 265 (223) | 447 (265) | NS | <0.0001 | NS |
| Fasting insulin, pmol/l | 65 (42) | 66 (49) | 63 (43) | 72 (41) | NS | 0.0341 | NS |
| Fasting ISR, pmol min−1 m−2 | 45 (29) | 58 (41) | 46 (32) | 53 (47) | NS | <0.0001 | NS |
| 2 h glucose, mmol/l | 5.9 (1.5) | 6.0 (2.0) | 6.7 (2.0) | 7.0 (2.8) | <0.0001 | NS | NS |
| Total insulin output, nmol/m | 27.9 (12.0) | 29.1 (13.1) | 25.3 (13.8) | 26.6 (15.0) | 0.0006 | 0.0023 | NS |
| Glucose sensitivity, pmol min−1 m−2 [mmol/l]−1 | 84 (66) | 84 (68) | 49 (44) | 41 (37) | <0.0001 | NS | NS |
| AIR, pmol/mmol | 47.4 (39.6) | 54.5 (35.5) | 29.2 (25.4) | 31.9 (27.7) | <0.0001 | 0.0342 | NS |
| Rate sensitivity, nmol m−2 [mmol/l]−1 | 2.2 (4.2) | 2.1 (4.1) | 2.4 (3.8) | 2.6 (4.1) | NS | NS | NS |
| Potentiation factor ratio | 1.3 (0.7) | 1.5 (0.9) | 1.3 (0.6) | 1.5 (0.6) | NS | 0.0017 | NS |
| Insulin sensitivity, ml min−1 m−2 | 448 (68) | 408 (82) | 449 (73) | 413 (49) | NS | <0.0001 | NS |
Data are presented as median (IQR)
pprogr, p value for the difference between progressors and non-progressors (regardless of age); page, p value for the difference between age groups (regardless of progression status); pg×a, p value for the progression × age interaction, by ANCOVA