Table 2.
Total (%) N = 81 |
Fatal (%) N = 67 |
Survived (%) N = 14 |
p-value | |
---|---|---|---|---|
Period | ||||
Pre-Pandemic, 27 Months (January 2018–March 2020) | 27 (33.33) | 22 (32.84) | 5 (35.71) | 0.835 |
Pandemic, 27 Months (April 2020–June 2022) | 54 (66.67) | 45 (67.16) | 9 (64.28) | 0.835 |
Demographic characteristics | ||||
Median Age (IQR) | 70 (61–79) | 69 (59–79) | 70 (64–77) | 0.685 |
Female Gender | 48 (59.3) | 39 (58.2) | 9 (64.3) | 0.674 |
Inflammatory markers | ||||
Median Procalcitonin (IQR) | 3.56 (1.08–22.81) | 4.00 (1.08–25.13) | 1.91 (1.08–4.63) | 0.183 |
Median CRP (IQR) | 213.6 (140.9–329.5) | 214.3 (150.3–301.6) | 174.4 (98.3–364.0) | 0.861 |
Clinical characteristics | ||||
Mechanical ventilation | 77 (95.06) | 66 (98.51) | 11 (78.57) | 0.002 |
COVID-19 | 38 (46.91) | 34 (50.75) | 4 (28.57) | 0.223 |
Fever > 38 °C | 47 (58.02) | 37 (55.22) | 10 (71.43) | 0.264 |
Comorbidity | 66 (81.48) | 54 (80.60) | 12 (85.71) | 0.654 |
Median Apache Score (IQR) | 20 (15–27) | 19.5 (15–24) | 27 (20–30) | 0.204 |
Malignancy | 36 (44.44) | 30 (44.78) | 6 (42.86) | 0.895 |
Healthcare associated | 51 (62.96) | 40 (59.70) | 11 (78.57) | 0.184 |
Infection site | ||||
Tracheal aspirate | 69 (85.18) | 61 (91.04) | 8 (57.14) | 0.001 |
Blood | 24 (29.63) | 17 (25.37) | 7 (50.00) | 0.066 |
Urine | 1 (1.23) | 1 (1.49) | 0 | N/A |
Antimicrobial resistance | ||||
Amikacin resistance | 65 (80.25) | 55 (82.09) | 10 (71.43) | 0.362 |
Gentamicin resistance | 65 (80.25) | 55 (82.09) | 10 (71.43) | 0.362 |
Meropenem resistance | 73 (90.12) | 62 (83.78) | 11 (78.57) | 0.111 |
Imipenem resistance | 73 (90.12) | 62 (83.78) | 11 (78.57) | 0.111 |
Ceftazidime resistance | 74 (91.36) | 62 (83.78) | 12 (85.71) | 0.409 |
Piperacillin/Tazobactam resistance | 74 (91.36) | 62 (83.78) | 12 (85.71) | 0.409 |
Ciprofloxacin resistance | 73 (90.12) | 62 (83.78) | 11 (78.57) | 0.067 |
Colistin resistance | 0 | 0 | 0 | N/A |
Significant values are in [bold].