Table 2.
Summary of Functional Assays Conducted During This Study and the Molecular Interactions of FH Assessed in Each Assay
| Assays | Binding to C3b | Competition With FB Binding and/or Displacement of Bb | Recruitment of FI to C3bBb | Recognition of Host Surface |
|---|---|---|---|---|
| C3b binding | + | − | − | − |
| DAA | + | + | − | − |
| Cofactor | + | − | + | − |
| AP immunoassay | + | + | + | − |
| Hemolysis | + | + | + | + |