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. 2022 Sep 21;21(12):1835–1845. doi: 10.1158/1535-7163.MCT-21-1021

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 1. Cytotoxic activity of (i) [225Ac]Ac-DOTA-2Rs15d alone or (ii) blocked with cold 2Rs15d; and (iii) nontargeting [225Ac]Ac-DOTA-R3B23 control probe on SKOV-3 cells determined via clonogenic (A and B) and DNA double-strand break (C and D) assays. Representative images (A) and SFs (B) of SKOV-3 cells from clonogenic assay. C, The average number of γH2AX-foci quantified per cell; NT - control cells nontreated with radioactivity. D, Representative images of detected γH2AX-foci in treated SKOV-3 cells. — Cytotoxic activity of (i) [²²⁵Ac]Ac-DOTA-2Rs15d alone or (ii) blocked with cold 2Rs15d; and (iii) nontargeting [²²⁵Ac]Ac-DOTA-R3B23 control probe on SKOV-3 cells determined via clonogenic (A and B) and DNA double-strand break (C and D) assays. Representative images (A) and SFs (B) of SKOV-3 cells from clonogenic assay. C, The average number of γH2AX-foci quantified per cell; NT - control cells nontreated with radioactivity. D, Representative images of detected γH2AX-foci in treated SKOV-3 cells.